DNA assembled into nanostructures such as tubes and origami-inspired shapes could someday find applications ranging from DNA computers to nanomedicine. However, these intriguing structures don’t persist long in biological environments because of enzymes called nucleases that degrade DNA. Now, researchers have designed DNA nanostructures that can heal themselves in serum. They report their results in ACS’ journal Nano Letters.
Someday, doctors could introduce DNA nanostructures to the human body to diagnose diseases or deliver medications, among other applications. But first, they must find a way to protect or repair the molecules when nucleases attack. Researchers have developed several approaches to stabilize the structures in serum, such as chemically modifying or coating the DNA. However, making this stabilized DNA can be expensive and time-consuming, and the modifications could affect the nanostructures’ biocompatibility or function. So, Yi Li and Rebecca Schulman wanted to develop a self-repair process that could substantially extend the lifetime of DNA nanostructures.